Stationary, Continuous, and Sequential Surface‐Enhanced Raman Scattering Sensing Based on the Nanoscale and Microscale Polymer‐Metal Composite Sensor Particles through Microfluidics: A Review

Surface-enhanced Raman scattering (SERS) is a label-free and accurate analytical technique for the detection of broad range various analytes such as, biomolecules, pesticides, petrochemicals, as well cellular other biological systems. A key component SERS analysis substrate which required to be equipped with plasmonic features metal nanostructures that directly interact light targeted analytes. Either nanoparticles can deposited on solid support (glass or silicon) suitable stationary dispersed in solution (freely moving nanoparticles). Besides these routinely utilizing substrates, polymer–metal composite particles are promising sustained where act plasmon-active (hence SERS-active) components polymer nanoparticles. Composite sensor provide 3D interaction possibilities analytes, stationary, continuous, sequential analysis, they reusable/regenerated. Therefore, this review focused experimental procedures development multiscale, uniform, reproducible together their application analysis. The microfluidic reaction highly versatile production uniform size-tunable particles, conducting